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Reversible lipidization for the oral delivery of salmon calcitonin

✍ Scribed by Jeff Wang; Donald Chow; Hashem Heiati; Wei-Chiang Shen

Book ID
114162179
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
819 KB
Volume
88
Category
Article
ISSN
0168-3659

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Biodegradable nanoparticles containing salmon calcitonin (sCT) were formulated using protein-fatty acid complexes, and their in vitro transport against a Caco-2 cell monolayer and the extent of in vivo oral uptake were assessed. Positively charged sCT was hydrophobically ion paired to form physical