Complexation hydrogels for intestinal delivery of interferon β and calcitonin
✍ Scribed by Noriyasu Kamei; Mariko Morishita; Hitomi Chiba; Nikhil J. Kavimandan; Nicholas A. Peppas; Kozo Takayama
- Book ID
- 113692653
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 293 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0168-3659
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Hydrogels comprised of poly(methacrylic acid) grafted with poly(ethylene glycol) (P(MAA-g-EG)) were characterized and examined for their potential as oral insulin carriers. Insulin loaded polymer (ILP) samples were made using two different polymer formulations. The values for the effective molecular
## Abstract Insulin transport across the epithelial cell layer in the small intestine was studied using insulin/transferrin conjugates with and without the presence of P(MAA__‐g‐__EG) microparticles in contact with a co‐culture of Caco‐2/HT29‐MTX cells. The insulin/transferrin conjugate was shown t