Comparison of the mode of action of ras p21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells
β Scribed by Naohisa Oku; Kozo Kaibuchi; Yasuo Fukumoto; Yuichi Hori; Hiroyuki Fujioka; Yoshimi Takai
- Book ID
- 115923945
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 581 KB
- Volume
- 269
- Category
- Article
- ISSN
- 0014-5793
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π SIMILAR VOLUMES
Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 m UCF1-C immediately and reversibly inhibited growth in these cells, wi
## Abstract Protein kinase Cβepsilon coordinately regulates changes in cell growth and shape. Cells overproducing protein kinase Cβepsilon spontaneously acquire a polarized morphology and extend long cellular membrane protrusions that are reminiscent of the morphology observed in __ras__βtransforme