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Effects of Transformation by p21 N-ras upon the Inositol Phospholipid and Adenylate Cyclase Signaling Pathways in NIH 3T3 Cells

✍ Scribed by SHIREEN-ANNE DAVIES; MILES D. HOUSLAY; MICHAEL J.O. WAKELAM

Book ID
119860977
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
162 KB
Volume
551
Category
Article
ISSN
0890-6564

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Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 m UCF1-C immediately and reversibly inhibited growth in these cells, wi