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Comparison of 13C Resolution and Sensitivity of HSQC and HMQC Sequences and Application of HSQC-Based Sequences to the Total 1H and 13C Spectral Assignment of Clionasterol

✍ Scribed by William F. Reynolds; Stewart McLean; Li-Lin Tay; Margaret Yu; Raul G. Enriquez; Dionne M. Estwick; Keith O. Pascoe

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 488 KB
Volume: 35
Category: Article
ISSN: 0749-1581
DOI: 10.1002/(sici)1097-458x(199707)35:7<455::aid-omr116>3.0.co;2-6

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✦ Synopsis

It is demonstrated that HSQC gives considerably better 13C resolution and sensitivity than HMQC for CH 2 groups of natural products, particularly when combined with linear prediction. Similarly, coupled HSQC spectra provide a useful method for the determination of 1H multiplet structure and consequent assignment of individual protons as axial or equatorial in fused cyclohexane rings. These and related techniques are used to assign 1H CH 2 and 13C spectra of the marine sterol clionasterol.

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