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Order parameters based on 13C1H, 13C1H2 and 13C1H3 heteronuclear dipolar powder patterns: a comparison of MAS-based solid-state NMR sequences

✍ Scribed by Justin Lorieau; Ann E. McDermott

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
506 KB
Volume
44
Category
Article
ISSN
0749-1581

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✦ Synopsis

Order parameters describing conformational exchange processes on the nanosecond to microsecond timescale can be obtained from powder patterns in solid-state NMR (SSNMR) experiments. Extensions of these experiments to magic-angle spinning (MAS) based high-resolution experiments have been demonstrated, which show a great promise for site-specific probes of biopolymers. In this study, we present a detailed comparison of two pulse sequences, transverse Manfield-Rhim-Elleman-Vaughn (T-MREV) and Lee-Goldburg cross-polarization (LGCP), using experimental and simulation tools to explore their utility in the study of order parameters. We discuss systematic errors due to passively coupled (13)C or (1)H nuclei, as well as due to B(1) inhomogeneity. Both pulse sequences can provide quantitative measurements of the order parameter, but the LGCP experiment is capable of greater accuracy provided that the B(1) field is highly homogeneous. The T-MREV experiment is far better compensated for B(1) inhomogeneity, and it also performs better in situations with limited signal.

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