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Comparative Sequence Analysis of the VHL Tumor Suppressor Gene

✍ Scribed by Emma R. Woodward; Alexander Buchberger; Steven C. Clifford; Laurence D. Hurst; Nabeel A. Affara; Eamonn R. Maher

Book ID
115615060
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
366 KB
Volume
65
Category
Article
ISSN
0888-7543

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✍ Maryse Bailly; Christine Bain; Marie-C. Favrot; Mehmet Ozturk πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 French βš– 917 KB

Somatic mutations of von Hippel Lindau (VHL) tumorsuppressor gene have been identified in kidney cancers from North America and Japan. We studied VHL gene mutation in 3 I kidney tumors from France. Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at AT base pairs. The frequenc