✦ LIBER ✦

Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in european kidney cancers

✍ Scribed by Maryse Bailly; Christine Bain; Marie-C. Favrot; Mehmet Ozturk

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 917 KB
Volume: 63
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910630510

No coin nor oath required. For personal study only.

✦ Synopsis

Somatic mutations of von Hippel Lindau (VHL) tumorsuppressor gene have been identified in kidney cancers from North America and Japan. We studied VHL gene mutation in 3 I kidney tumors from France. Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at AT base pairs. The frequency and the spectrum of mutations identified in kidney tumors from EuroDe were similar to those renorted for tumok from other geographical locations.

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