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Comparative pharmacokinetics of coumarin anticoagulants XLIV: Dose-dependent pharmacokinetics of warfarin in rats

โœ Scribed by Kanji Takada; Gerhard Levy

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
696 KB
Volume
69
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES

Comparative pharmacokinetics of coumarin
Comparative pharmacokinetics of coumarin anticoagulants XLIII: Concentration-dependent hepatic uptake of warfarin in rats
โœ Kanji Takada; Gerhard Levy ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 385 KB

The purpose of this study was to determine if hepatic warfarin uptake, which has a major quantitative effect on warfarin distribution in rats, is concentration dependent. Adult male rats received either 0.1 or 1.0 mg of racemic warfarin/kg iv and were killed 6 hr later. With increasing dose, the con