Comparative pharmacokinetics of coumarin anticoagulants XLI: Effect of phenobarbital on systemic availability of orally administered dicumarol in rats

✍ Scribed by James W. Crow; Milo Gibaldi; Gerhard Levy

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 547 KB
• Volume: 68
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600680811

✦ Synopsis

NH of amide at Cp or N,H), and 10.95 (broad s, lH, NIH or NH of amide a t Co) ppm. (See Table 111 for analyses.)

Pharmacology-Antiarrhythmic Actiuity-With the method of Lawson (5), fibrillations were induced in 20-30-g male mice by exposure to chloroform vapor until respiration ceased. The heart was exposed, and the cardiac rate was determined with a binocular microscope. Mice with cardiac rates >200 beats/min were considered unprotected (Table IV).

Local Anesthetic Actiuity-The guinea pig wheal method of Bulbring and Wajda (6) was used to determine the activity. The back of the guinea pig was shaved 1 day prior to the test, and 0.25 ml of the aqueous drug solution was administered intradermally a t two sites along the midline. The resulting wheals were tested by pricking the area six times with a pin a t 5-min intervals for 1 hr. Local anesthesia was present if the pinprick did not elicit a skin twitch. The number of pinpricks that failed to elicit a response was then recorded a t each time interval (Table V).