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Colonic adenoma in Cowden's disease with a germline mutation of the PTEN/MMACI tumor suppressor gene

✍ Scribed by Chi, SG; Kim, HJ; Kim, YW; Dong, SH; Kim, BH; Lee, JI; Chang, YW; Chang, R


Book ID
122515395
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
176 KB
Volume
114
Category
Article
ISSN
0016-5085

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## Background: Germ-line and sporadic mutations in the tumor suppressor gene pten (also known as mmac or tep1), which encodes a dual-specificity phosphatase, cause a variety of cancers such as cowden disease, glioblastoma, endometrial carcinoma and prostatic cancer. pten is widely expressed, and co