Collagenolytic activities in methylcholanthrene-induced fibrosarcomas in mice
β Scribed by Kingsley R. Labrosse; Irvin E. Liener
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 644 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0300-8177
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No attempt will be made by the authors to discriminate between induction or acceleration of the neoplasms discussed in this paper. It appears that pulmonary tumors which occur spontaneously in RFM mice in high incidence late in life are " accelerated " rather than " induced ". The other tumors are p
Eighteen clones of a methylcholanthrene-induced murine fibrosarcoma (3AM) which were heterogeneous with respect to metastatic potentials and in vivo growth rates were examined for five different protease activities: acid protease (cathepsin D), BANA hydrolase (cathepsin B), neutral protease, collage
The DNA of 22 fibrosarcomas, newly induced in 0ALWc mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonuc
## Abstract We have shown previously, with Xβchromosome linked phosphoglycerate kinase (PGK) cell markers, that the fibrosarcomas induced in mice by subcutaneous injection of 0.2β2.0 mg of methylcholanthrene (MCA) dissolved in olive oil had a multicellular origin. In this study we used a constant d
A number of derivatives of 3-methylcholanthrene have been tested for carcinogenic action by injection into CS7 black mice. Iand 2-Hydroxy-3-methylcholanthvene and 3-rnethylcholanthrene-Iand 2-one were active carcinogens, but cis-1,2-dihydroxy-3-methylcholanthrene showed only weak activity. The hydro