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The carcinogenic activities in mice of compounds related to 3-methylcholanthrene

โœ Scribed by P. Sims

Publisher
John Wiley and Sons
Year
1967
Tongue
French
Weight
219 KB
Volume
2
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

A number of derivatives of 3-methylcholanthrene have been tested for carcinogenic action by injection into CS7 black mice. Iand 2-Hydroxy-3-methylcholanthvene and 3-rnethylcholanthrene-Iand 2-one were active carcinogens, but cis-1,2-dihydroxy-3-methylcholanthrene showed only weak activity. The hydrocarbon, 3-methylcholanthrylene (1,2-dehydro-3-methylcholanthrene), was an active carcinogen. I I ,12-Epoxy-II,I2-dihydro-3-methylcholanthrene showed weak carcinogenic activity whereas cis-11,12-dihydro-ll,12-dihydroxy-3-methylcholanthrene was inactive.

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