𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The carcinogenic activities in mice of compounds related to benz[a]anthracene

✍ Scribed by E. Boyland; P. Sims

Publisher
John Wiley and Sons
Year
1967
Tongue
French
Weight
323 KB
Volume
2
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

The carcinogenic activities of a number of aromatic hydrocarbons have been compared with some metabolic intermediates by subcutaneous injection into CS7 black mice. The rnonohydroxymethyl derivatives of 7,12-dimethylbenz[a]anthracene and some related compounds were found to be active carcinogens, but were much less so than the parent hydrocarbon. Epoxides formed at the K-region of chrysene, benz [a]anthracene, 7-methylbenz[a]anthracene and dibent [a,h]atithracene produced tumours when given at highdose levels, but were not as active as the parent hydrocarbons. The epoxide derived from phenanthrene was inactive.

On a compare' I'activite carcinoghne d'un certain nombre d 'hydrocarbures aromatiques avec celle de quelques produits de Ieur me'tabolisme interme'diaire, par injection sous-cutunPe d des souris CS7. II a Pte' constate' que les derives monohydroxymkthyle's du 7,12 dime'thylbenzo ( a ) anthrachne et certains composes voisins Ptaient d'actifs carcinoghnes mais moins que I'hydrocarbure primitif. Les e'poxydes forme's dans la re'gion K du chryshne, du benzo (a)anthrachne, du 7-me'thylhenzo (a)anthrachne et du dibenzo (a,h)anthracPne ont produit des tumeurs lorsqu'ils Ptaient administre's a doses e'levges, mais n'e'taient pas aussi actifs que les hydrocarbures primitifs. L'e'poxyde de'rive' du phe'nanthrhnr 6tait inactif.

πŸ“œ SIMILAR VOLUMES

The carcinogenic activities in mice of c
The carcinogenic activities in mice of compounds related to 3-methylcholanthrene
✍ P. Sims πŸ“‚ Article πŸ“… 1967 πŸ› John Wiley and Sons 🌐 French βš– 219 KB πŸ‘ 1 views

A number of derivatives of 3-methylcholanthrene have been tested for carcinogenic action by injection into CS7 black mice. Iand 2-Hydroxy-3-methylcholanthvene and 3-rnethylcholanthrene-Iand 2-one were active carcinogens, but cis-1,2-dihydroxy-3-methylcholanthrene showed only weak activity. The hydro

Evaluation of the carcinogenic activity
Evaluation of the carcinogenic activity of the hydroxymethyl derivatives of 7,12-dimethylbenz(A) anthracene by an in vitro-in vivo technique
✍ A. Flaks; J. M. Hamilton; D. B. Clayson; P. Sims πŸ“‚ Article πŸ“… 1972 πŸ› John Wiley and Sons 🌐 French βš– 272 KB

## Abstract 7,12‐Dimethylbenz(a)anthracene and three of its metabolites were tested for carcinogenic activity by in vitro incubation with murine pulmonary tissue for 2 days followed by implantation of the explants into isologous mice. 7‐Hydroxymethyl‐12‐methylbenz(a) anthracene and 12‐hydroxymethyl

Mineralisation, during incubation, of th
Mineralisation, during incubation, of the organic nitrogen compounds in soils as related to soil pH
✍ A. H. Cornfield πŸ“‚ Article πŸ“… 1959 πŸ› John Wiley and Sons 🌐 English βš– 165 KB πŸ‘ 1 views

## Abstract Mineral nitrogen accumulation (mineralised nitrogen) during incubation, with and without added chalk (calcium carbonate), of 25 cultivated soils of varying texture, pH and total nitrogen content was determined. There was little difference in nitrogen mineralised per unit of total soil n