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Evaluation of the carcinogenic activity of the hydroxymethyl derivatives of 7,12-dimethylbenz(A) anthracene by an in vitro-in vivo technique

✍ Scribed by A. Flaks; J. M. Hamilton; D. B. Clayson; P. Sims

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
272 KB
Volume
10
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

7,12‐Dimethylbenz(a)anthracene and three of its metabolites were tested for carcinogenic activity by in vitro incubation with murine pulmonary tissue for 2 days followed by implantation of the explants into isologous mice. 7‐Hydroxymethyl‐12‐methylbenz(a) anthracene and 12‐hydroxymethyl‐7‐methylbenz(a) anthracene were as potently carcinogenic as the parent hydrocarbon but 7,12‐dihydroxymethylbenz(a)‐anthracene was inactive. These results are discussed in the light of current theories of metabolic activation of the hydrocarbon.

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