Effect of sodium cobaltinitrite on the minimal carcinogenic dose50 (MCD50) of methylcholanthrene in albino mice

✍ Scribed by Raymond F. Orzechowski; Ronald F. Gautieri; David E. Mann Jr.

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 395 KB
• Volume: 53
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600530409

✦ Synopsis

colored compounds. Based essentially upon this property, the production of these formazans by various reducing systems has led to a diverse range of biological and chemical applications. Lakon (1) has used triphenyltetrazolium chloride to detect viability of seeds, while Straus, Cheronis, and Straus (2) have applied tetrazolium salts in the study of carcinomatous tissue.

Chemical applications of tetrazolium salts include the quantitative analysis of reducing sugars (3), ketol steroids (4), and ascorbic acid (5). Rosenkrantz (6) has compared the effect of struc-