Bcl-6 (LAZ-3) and Bcl-2 gene rearrangements have been respectively reported in 20-35 per cent and 10-25 per cent of diffuse large B-cell lymphomas (DLBCLs). Although these genetic lesions have been associated with different clinical outcomes (i.e., more favourable in Bcl-6 rearranged cases and poore
Coexistent Rearrangements of c-MYC,BCL2, andBCL6Genes in a Diffuse Large B-Cell Lymphoma
โ Scribed by Chiyoko Ueda; Momoko Nishikori; Toshio Kitawaki; Takashi Uchiyama; Hitoshi Ohno
- Publisher
- Carden Jennings Publishing
- Year
- 2004
- Tongue
- English
- Weight
- 346 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0925-5710
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๐ SIMILAR VOLUMES
## Abstract ## BACKGROUND In Western populations, rearrangement of the __BCL__โ6 gene can be identified in 20โ40% of patients with diffuse large Bโcell lymphoma (DLBCL). Analysis of the __BCL__โ6 gene has revealed the presence of point mutations or small deletions in 70% of DLBCL tumors; however,
## Abstract Recent studies have suggested that chromosomal aberrations of the MYC gene locus indicate an unfavorable prognosis in diffuse large Bโcell lymphoma (DLBCL). However, there have been few reports on MYC translocation in Chinese patients. One hundred and six cases of DLBCLs were analyzed u