Bcl-6 (LAZ-3) and Bcl-2 gene rearrangements have been respectively reported in 20-35 per cent and 10-25 per cent of diffuse large B-cell lymphomas (DLBCLs). Although these genetic lesions have been associated with different clinical outcomes (i.e., more favourable in Bcl-6 rearranged cases and poore
โฆ LIBER โฆ
Bcl-2 gene rearrangement: Diagnostic implications in a case of a large cell diffuse lymphoma appearing in leukemic phase
โ Scribed by F. A. Gonzalez; A. Villegas; B. Armada; C. Garcia; J. Perez; E. Anguita
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 667 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0361-8609
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Identifying the various genetic alterations that contribute to lymphomagenesis is key to our improved understanding of the biological behavior of the disease. Recently, we and others have defined a tumor suppressor region on the short arm of chromosome 9 harboring a cluster of genes, including MTAP,