## Abstract Recent studies have suggested that chromosomal aberrations of the MYC gene locus indicate an unfavorable prognosis in diffuse large Bβcell lymphoma (DLBCL). However, there have been few reports on MYC translocation in Chinese patients. One hundred and six cases of DLBCLs were analyzed u
Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes
β Scribed by Ako Kikuchi; Naoya Nakamura; Tetsuo Kuze; Yoshikazu Sasaki; Masafumi Abe; Hitoshi Ohno; Takashi Akasaka; Shigeo Nakamura; Koichi Ohshima; Kiyoshi Ando
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 979 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0145-2126
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The sequence of the exon I lintron I boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8; 14) (q24q32) and the other with t(8;22) (q24;q I I). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding
## Abstract Richter's syndrome (RS) represents the transformation of chronic lymphocytic leukaemia (CLL) to aggressive lymphoma and is mostly represented by diffuse large Bβcell lymphoma (DLBCL), with a postβgerminal centre (GC) phenotype, clonally related to the preβexisting CLL. RS has a very poo
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