Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24

✍ Scribed by John F. Bradley; Paul G. Rothberg; Marc Ladanyl; R. S. K. Chaganti

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 303 KB
• Volume: 7
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870070303

✦ Synopsis

The sequence of the exon I lintron I boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8; 14) (q24q32) and the other with t(8;22) (q24;q I I). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding site in intron I , which is a frequent target for mutational inactivation in endemic Burkitt's lymphoma (eBL). The translocations at 8q24, and multiple mutations in the exon Ihntron I boundary region, are reminiscent of similar findings in eBL. The same underlying oncogenic event that occurs in most eBLs is thus found in some DLCLs.