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Cloning of the hamster p16 gene 5′ upstream region and its aberrant methylation patterns in pancreatic cancer

✍ Scribed by Madoka Hanaoka; Kyoko Shimizu; Mayumi Shigemura; Ayumi Kato; Hiromasa Fujii; Kanya Honoki; Toshifumi Tsujiuchi

Book ID: 116290805
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 262 KB
Volume: 333
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2005.06.034

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## Abstract Alterations of the __Rassf1a__ gene were investigated in pancreatic duct adenocarcinomas (PDAs) induced by N‐nitrosobis(2‐oxopropyl)amine (BOP) in hamsters. Female Syrian golden hamsters received 70 mg/kg BOP, followed by repeated exposures to an augmentation pressure regimen consisting