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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

โœ Scribed by Sherrington, R.; Rogaev, E. I.; Liang, Y.; Rogaeva, E. A.; Levesque, G.; Ikeda, M.; Chi, H.; Lin, C.; Li, G.; Holman, K.


Book ID
109793357
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
825 KB
Volume
375
Category
Article
ISSN
0028-0836

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## Background: Early-onset familial alzheimer's disease (eofad) is linked to mutations in three autosomal dominant genes: ps1, ps2 and app. the clinical presentation and age of onset of mutations is variable. ## Objectives: The aim of this report is to describe a novel ps1 mutation believed to be