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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

โœ Scribed by Goate, Alison; Chartier-Harlin, Marie-Christine; Mullan, Mike; Brown, Jeremy; Crawford, Fiona; Fidani, Liana; Giuffra, Luis; Haynes, Andrew; Irving, Nick; James, Louise


Book ID
109767335
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
356 KB
Volume
349
Category
Article
ISSN
0028-0836

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We sequenced the entire coding region of the amyloid precursor protein (APP) genes of 11 unrelated patients with Japanese familial Alzheimer's disease (FAD) in order to determine the exact frequency of known APP gene mutations and to search for novel mutations responsible for FAD. Three out of 11 (2