Progressive cerebral deposition of -amyloid peptide either in blood vessels or around neurites is one of the most important features of Alzheimer's disease (AD). The -peptide, known as A or A4, is produced by proteolytic cleavage of the amyloid precursor protein (APP). Two APP processing pathways
✦ LIBER ✦
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
✍ Scribed by Citron, Martin; Oltersdorf, Tilman; Haass, Christian; McConlogue, Lisa; Hung, Albert Y.; Seubert, Peter; Vigo-Pelfrey, Carmen; Lieberburg, Ivan; Selkoe, Dennis J.
- Book ID
- 109782743
- Publisher
- Nature Publishing Group
- Year
- 1992
- Tongue
- English
- Weight
- 414 KB
- Volume
- 360
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/360672a0
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