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β-Amyloid precursor protein of Alzheimer's disease in cultured bovine oligodendrocytes

✍ Scribed by M. Mizuguchi; K. Ikeda; Seung U. Kim

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
866 KB
Volume
32
Category
Article
ISSN
0360-4012

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✦ Synopsis

The production of P-amyloid precursor protein (PAPP) in cultured oligodendrocytes isolated from adult bovine brains was examined by immunohistochemistry and immunoblotting. Immunostaining of oligodendrocytes with antibodies specific for the carboxy terminus of p APP demonstrated positive immunoreactivity of oligodendroglial cytoplasm. Immunoblot analysis of cellular extracts detected two distinct bands with estimated molecular weight of 118 and 105 kDa. The amount of these PAPP subspecies increased considerably in response to their attachment to the poly-L-lysine substratum.

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Progressive cerebral deposition of ␤-amyloid peptide either in blood vessels or around neurites is one of the most important features of Alzheimer's disease (AD). The ␤-peptide, known as A␤ or A4, is produced by proteolytic cleavage of the amyloid precursor protein (APP). Two APP processing pathways