Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease
โ Scribed by H. Poustchi; A. Mohamadkhani; S. Bowden; G. Montazeri; A. Ayres; P. Revill; G. C. Farrell; S. Locarnini; J. George; R. Malekzadeh
- Book ID
- 108886153
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 109 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1352-0504
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## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in
Spontaneous mutations of hepatitis B virus (HBV) could influence the severity of liver disease. Since the basal core promoter (BCP) and the precore (Pc) regions are important for viral replication, these regions were examined for naturally occurring mutations and were correlated with the genotype, e
and who developed recurrent HBV infection were evaluated for the study. Patients infected Abbreviations: HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; nt, nucleowith hepatitis C or delta virus were excluded, leaving a study group tide; HBeAg, hepatitis B e antigen; PCR, polymerase chai