## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in
Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation
β Scribed by J S McMillan; D S Bowden; P W Angus; G W McCaughan; Associate Professor S A Locarnini
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 240 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
β¦ Synopsis
and who developed recurrent HBV infection were evaluated for the study. Patients infected Abbreviations: HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; nt, nucleowith hepatitis C or delta virus were excluded, leaving a study group tide; HBeAg, hepatitis B e antigen; PCR, polymerase chain reaction; BCP, basic core proof 15 in total. Of these, 9 were infected with HBV containing a Gmoter; HBcAg, hepatitis B core antigen; CTL, cytotoxic T lymphocyte; HLA, human lymphoto-A mutation at nt 1896 (precore mutant virus) and 6 with HBV cyte antigen.
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To investigate the meaning of the mutations in the enhancer 2/core promoter (Enh2/CP) region of hepatitis B virus (HBV) during the chronic HBV infection, mutations were examined in the Enh2/ CP region (carboxyl half of X region) and their correlation with mutations in the precore and core regions in
Spontaneous mutations of hepatitis B virus (HBV) could influence the severity of liver disease. Since the basal core promoter (BCP) and the precore (Pc) regions are important for viral replication, these regions were examined for naturally occurring mutations and were correlated with the genotype, e
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