Clinical significance of dihydropyrimidine dehydrogenase and thymidylate synthase expression in patients with pancreatic cancer
β Scribed by Osamu Nakahara; Hiroshi Takamori; Hiroshi Tanaka; Yasuo Sakamoto; Yoshiaki Ikuta; Satoshi Furuhashi; Masayuki Watanabe; Toru Beppu; Masahiko Hirota; Keiichiro Kanemitsu; Hideo Baba
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 293 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1341-9625
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## Abstract Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA __de novo__ synthesis and the salvage pathway in cancer cells, respectively. Intratumoral TS and DPD gene expressions were evaluated to determine the correlation between the expression of th
## Abstract Cytotoxic effect of 5βfluorouracil 5βFU is mediated through inhibition of thymidylate synthase (TS), and 5βFU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5βFU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30