Influence of thymidylate synthase and p53 protein expression on clinical outcome in patients with colorectal cancer
✍ Scribed by R. Broll; P. Busch; M. Duchrow; E. Oevermann; O. Schwandner; S. Farke; H. P. Bruch; U. Windhövel
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 380 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0179-1958
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## Abstract While several studies have reported that thymidylate synthase (TS) tumour expression can be a reliable predictive marker of clinical response to 5‐Fluorouracil (5‐FU) for advanced colorectal cancer patients, only a few studies that searched for predictive factors of irinotecan (CPT‐11)
## Abstract ## Background Cyclooxygenase (COX)‐2 is believed to be an important enzyme related to the pathogenesis of colorectal cancer (CRC). p53 has been reported to be a negative regulator of COX‐2 expression in in vitro studies. The aim of this study was to investigate COX‐2 expression and its