It is essential for actively proliferating cells to increase their rate of DNA synthesis to progress through the cell cycle. This is reflected in the increased uracil usage that is a common feature in solid tumours. Thymidine phosphorylase (TP) anabolises formation of pyrimidine nucleosides availabl
โฆ LIBER โฆ
Clinical significance of thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in transitional cell cancer
โ Scribed by Yasuhiro Hirano; Shinji Kageyama; Tomomi Ushiyama; Kazuo Suzuki; Kimio Fujita
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 246 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
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## Abstract ## Objectives: To evaluate whether two molecular biomarkers, thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD), could be clinically useful in predicting and improving the chemotherapeutic outcome of the oral fluoropyrimidine capecitabine (5โฒโDFUR or Xelodaยฎ), in th