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Clinical implication of nucleophosmin gene mutation and Flt-3 internal tandem duplication in a cohort of Egyptian AML patients

✍ Scribed by Mervat M. Khorshied, Wael A. Said, Hebat Allah M. Shaaban

Book ID: 120915367
Publisher: Springer-Verlag
Year: 2012
Tongue: English
Weight: 390 KB
Volume: 22
Category: Article
ISSN: 1618-5641
DOI: 10.1007/s00580-012-1439-0

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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte