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Chrysin inhibits expression of hypoxia-inducible factor-1 through reducing hypoxia-inducible factor-1 stability and inhibiting its protein synthesis

✍ Scribed by Fu, B.; Xue, J.; Li, Z.; Shi, X.; Jiang, B.-H.; Fang, J.

Book ID
126227874
Publisher
American Association for Cancer Research
Year
2007
Tongue
English
Weight
304 KB
Volume
6
Category
Article
ISSN
1535-7163

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## Abstract Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia‐inducible factor‐1Ξ± (HIF‐1Ξ±) in normoxia. In this study, under hypoxic conditions (1% O~2~), we examined the effect of quercetin on the i