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Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1

✍ Scribed by Liu, Yu; Higashitsuji, Hiroaki; Higashitsuji, Hisako; Itoh, Katsuhiko; Sakurai, Toshiharu; Koike, Kazuhiko; Hirota, Kiichi; Fukumoto, Manabu; Fujita, Jun


Book ID
120229446
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
697 KB
Volume
432
Category
Article
ISSN
0006-291X

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✍ Dae-Hee Lee; Yong J. Lee πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 285 KB

## Abstract Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia‐inducible factor‐1Ξ± (HIF‐1Ξ±) in normoxia. In this study, under hypoxic conditions (1% O~2~), we examined the effect of quercetin on the i