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Overexpression of hypoxia-inducible factor-1 alpha in gastric adenocarcinoma

✍ Scribed by Naomi Urano; Yoshiyuki Fujiwara; Yuichirou Doki; Masaki Tsujie; Hirofumi Yamamoto; Hiroshi Miyata; Shuji Takiguchi; Takushi Yasuda; Masahiko Yano; Morito Monden

Publisher: Springer
Year: 2006
Tongue: English
Weight: 775 KB
Volume: 9
Category: Article
ISSN: 1436-3291
DOI: 10.1007/s10120-005-0356-1

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## Abstract ## BACKGROUND Hypoxia occurs in association with cancer development, the result being a more aggressive and metastatic cancer phenotype. Hypoxia, which activates hypoxia‐inducible factor‐1 alpha (HIF‐1α), is associated with a number of cellular changes including increased apoptotic res