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Dimethyl fumarate inhibits the expression and function of hypoxia-inducible factor-1α (HIF-1α)

✍ Scribed by Zhao, Guangzong; Liu, Yao; Fang, Jun; Chen, Yunzhen; Li, Huazhuang; Gao, Kehai

Book ID: 121526214
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 986 KB
Volume: 448
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2014.02.062

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## Abstract Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia‐inducible factor‐1α (HIF‐1α) in normoxia. In this study, under hypoxic conditions (1% O~2~), we examined the effect of quercetin on the i