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Chronotherapy with 5-fluorouracil and folinic acid in advanced colorectal carcinoma

✍ Scribed by Sigrid Adler; Susanne Lang; Irmgard Langenmayer; Bernolf Eibl-Eibesfeldt; Waltraud Rump; Bertold Emmerich; Dr. Michael Hallek

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
757 KB
Volume
73
Category
Article
ISSN
0008-543X

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Randomized phase III Study of 5-fluorour
Randomized phase III Study of 5-fluorouracil plus high dose folinic acid versus 5-fluorouracil plus folinic acid plus methyl-lomustine for patients with advanced colorectal cancer
✍ Dennie V. Jones; Roger J. Winn; Barry W. Brown; Lawrence B. Levy; Reginald P. Pu πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 501 KB

Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized