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Preclinical and clinical evaluation of 5-fluorouracil biochemical modulation with folinic acid and hydroxyurea for patients with colorectal carcinoma

✍ Scribed by Daniele Matei; Nabil Hagag; Stefan Madajewicz; Naveed Chowhan; Patricia Hentschel; Louis Avvento; Patricia Burns; John Fiore; William Lipera; Hosein Zarrabi


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
504 KB
Volume
76
Category
Article
ISSN
0008-543X

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Randomized phase III Study of 5-fluorour
✍ Dennie V. Jones; Roger J. Winn; Barry W. Brown; Lawrence B. Levy; Reginald P. Pu πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 501 KB

Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized