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Etoposide, folinic acid, and 5-fluorouracil in carboplatin-pretreated patients with advanced gastric cancer

✍ Scribed by Hansjochen Wilke; Peter Preusser; Michael Stahl; Andreas Harstrick; Hans-Joachim Meyer; Wolf Achterrath; Hans-Joachim Schmoll; Siegfried Seeber


Publisher
Springer
Year
1991
Tongue
English
Weight
183 KB
Volume
29
Category
Article
ISSN
0344-5704

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Thirty-four consecutive patients with measurable advanced gastric cancer were treated in a disease oriented Phase II study with high-dose folinic acid (HDFA) 300 mg/m2 10 min. inf., followed immediately by etoposide 120 mg/m2 50 min. inf., followed immediately by 5-fluorouracil (5-FU) 500 mg/m2 10 m

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Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized