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Chromosome translocation (2;13) (q37;q14) in a disseminated alveolar rhabdomyosarcoma

✍ Scribed by R. Engel; J. Ritterbach; D. Schwabe; F. Lampert

Publisher
Springer
Year
1988
Tongue
English
Weight
744 KB
Volume
148
Category
Article
ISSN
0340-6997

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✦ Synopsis

Chromosome analysis of tumour cells in the bone marrow of a 13.5-year-old girl (without a primary tumour) revealed a pseudo-diploid or pseudo-tetraploid karyotype with a translocation involving the long arms of chromosomes 2 and 13: t(2;13)(q37;q14). This finding enabled the diagnosis of a disseminated alveolar rhabdomyosarcoma (RMS) to be established. The patient was treated by cytotoxic chemotherapy, went into complete remission, but died of relapse 14 months after diagnosis. As several cases with this translocation have been described recently, this additional report confirms that t(2;13) is specific for the alveolar subtype of RMS.

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