Rhabdomyosarcoma, a small-. round-cell tumor of skeletal muscle, is the most common soft tissue sarcoma found in children. A specific and unique chromosomal translocation, t(2;13)(q35;q14), has been described cytogenetically in a subset of these tumors and is most often associated with the alveolar
Chromosomal sublocalization of the 2;13 translocation breakpoint in alveolar rhabdomyosarcoma
β Scribed by David N. Shapiro; Marc B. Valentine; Jack E. Sublett; Anne E. Sinclair; A. Thomas Look; Alan M. Tereba; Hans Scheffer; Charles H. C. M. Buys
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 882 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1045-2257
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Cytogenetic studies of the pediatric solid tumor alveolar rhabdomyosarcoma have demonstrated the presence of a consistent chromosomal translocation, t(2 I3)(q35;q 14). We recently identified PAX3 and FKHR as the genes on chromosomes 2 and I 3, respectively, that are juxtaposed by this translocation.
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