Chromosome Changes in the Terminal Stages of Chronic Granulocytic Leukaemia
โ Scribed by Lawler, S. D. ;Galton, D. A. G.
- Book ID
- 114687727
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Weight
- 479 KB
- Volume
- 179
- Category
- Article
- ISSN
- 0001-6101
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๐ SIMILAR VOLUMES
In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, wi
Four cases of C.G.L. in which banding of the Ph1 chromosome was performed were found to have variation from the usual 9/22 translocation pattern. All 4 cases showed a rearrangement involving at least 3 chromosomes, 2 of which were a9 and a22. One of these cases had in addition an XYY karyotype in th