Molecular biology of Philadelphia chromosome in chronic granulocytic leukaemia and acute lymphoblastic leukaemia

✍ Scribed by S. Eridani; L. M. Wiedemann; L. C. Chan; R. G. Dalton; K. K. Karhi

• Book ID: 104735106
• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 447 KB
• Volume: 1
• Category: Article
• ISSN: 0920-9069
• DOI: 10.1007/bf00351119

✦ Synopsis

In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, with increased tyrosine kinase activity. Such DNA rearrangement, with a p210 protein synthesis, is also found in cases of Philadelphia-positive acute lymphoblastic leukemia (ALL), but in apparently similar cases the bcr gene is not rearranged, and a novel p190 abl-related protein can be found; c-abl rearrangement has also been observed.

It is thus established that correlations between cytogenetic and molecular events can be found in CGL and ALL, as in other haemopoietic malignancies: translocation and possible rearrangement of the c-abl oncogene seem of particular importance in this case.

Chronic granulocytic leukaemia