Autoradiographic Studies of the Chromosomes in Chronic Granulocytic Leukaemia
โ Scribed by HAINES, MARY
- Book ID
- 109645252
- Publisher
- Nature Publishing Group
- Year
- 1965
- Tongue
- English
- Weight
- 274 KB
- Volume
- 207
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/207552b0
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๐ SIMILAR VOLUMES
A 51/2-year-old boy is presented with chronic granulocytic leukaemia and blastic transformation whose clinical course is complicated by meningeal leukaemia. In the authors' opinion prophylactic central nervous system therapy should be part of the initial therapy of blastic transformation.
In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, wi
Four cases of C.G.L. in which banding of the Ph1 chromosome was performed were found to have variation from the usual 9/22 translocation pattern. All 4 cases showed a rearrangement involving at least 3 chromosomes, 2 of which were a9 and a22. One of these cases had in addition an XYY karyotype in th