Chromosome aberrations in 35 primary ovarian carcinomas

✍ Scribed by Tanja Pejovic; Sverre Heim; Felix Mitelman; Nils Mandahl; Ulla-Maria Flodérus; Stefan Furgyik; Helena Willén; Bo Baldetorp; Anna Himmelmann; Bengt Elmfors; Göran Helm

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 988 KB
• Volume: 4
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870040108

✦ Synopsis

Cytogenetic analysis was performed on short-term cultures of primary ovarian carcinomas from 62 patients. Cytogenetic analysis was successful in 59 cases. Clonal chromosome aberrations were detected in 35 tumors. Only numerical changes or a single structural change were found in five carcinomas: trisomy I 2 was the sole anomaly in two tumors, one tumor had the karyotype 5O,XX, + 5, + 7. -!-I 2, + 14, a fourth tumor had a balanced t( I 5). and the fifth tumor had an unbalanced t ( 8 I 5). The fact that four of these five carcinomas were well differentiated suggests that simple karyotypic changes are generally characteristic of these less aggressive ovarian tumors. The majority of the cytogenetically abnormal tumors (n = 30) had complex karyotypes, with both numerical and structural aberrations and often hypodiploid or near-triploid stemlines. The numerical imbalances (comparison with the nearest euploid number) were mostly losses, in order of decreasing frequency -17, -22, -I 3, -8, -X, and -14. The structural aberrations were mostly deletions and unbalanced translocations. Recurrent loss of genetic material affected chromosome arms Ip, 3p. 6q. and I Ip. The breakpoints of the clonal structural abnormalities clustered t o several chromosome bands and segments: I9p I 3, I I p I 3-1 5, I92 1-23, I p36. 19q I 3, 3p I2-13, and 6q2 1-23. The most consistent change (I 6 tumors) was a I9p + marker, and in I 2 of the tumors the I9p + markers looked alike. Genes Chrorn Cancer 458-68 (I 992).