✦ LIBER ✦

Chromosome aberrations in metastatic ovarian cancer: Relationship with abnormalities in primary tumors

✍ Scribed by M. Josefa Bello; Juan A. Rey

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Volume: 45
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910450111

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Twenty malignant effusions secondary to ovarian cancer have been cytogenetically analyzed directly and after short in vitro culture. With the exception of one sample characterized by trisomy 3, all cases displayed clonal structural rearrangements. Chromosomes 1 and 3 were most frequently involved in the genesis of markers. Abnormalities of chromosomes 5, 6, 9, 11 and 12 were also recurrently found, and double minutes (DM) were observed in 2 samples. Our results agree with previous findings on the preferential involvement of chromosomes 1, 3 and 6 in ovarian carcinomas, and suggest that rearrangements of certain chromosomes are non‐random but are secondary to the malignant progression of these tumors.

📜 SIMILAR VOLUMES

Intra-abdominal tumor dissemination patt

Intra-abdominal tumor dissemination pattern and surgical outcome in 214 patients with primary ovarian cancer

✍ Jalid Sehouli; Filiz Senyuva; Christina Fotopoulou; Ulf Neumann; Carsten Denkert 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB

Measurement of tumor cell activity in sh

Measurement of tumor cell activity in short-term primary culture. Clinical significance in women with ovarian cancer

✍ Soo-Keat Khoo; Terence Hurst; Eric V. Mackay; Maurice J. Webb; Graeme Dickie; Jo 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 578 KB

Surgical resection of the primary tumor,

Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancer

✍ Hannah W. Hazard; Seema R. Gorla; Denise Scholtens; Krystyna Kiel; William J. Gr 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 1 views

Identification of oncofetal fibronectin

Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer : Detection in ascitic fluid and localization to primary sites and metastatic implants

✍ Andrew W. Menzin; J. Ricardo Loret de Mola; Warren B. Bilker; James E. Wheeler; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 373 KB 👁 2 views

## Background: The mechanisms by which metastatic ovarian cancer adheres to peritoneal surfaces are not well understood. a role for tumor-derived extracellular matrix adhesive molecules such as fibronectin (fn) has been proposed. because oncofetal fibronectin (onffn) isoforms function in the adhesi

Ki-67 staining in benign, borderline, ma

Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: Correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D

✍ Sonja C. Henzen-Logmans; Elly J. H. Fieret; Els M. J. J. Berns; Maria E. L. van 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 652 KB

Ki-67 immunoreactivity was studied in relation to immunohistochemically assessed expression of epidermal-growth-factor receptor (EGFR), estrogen receptor (ER) progesterone receptor (PgR) and cytosolic levels of cathepsin D in advanced human ovarian adenocarcinomas, borderline and benign cystadenomas

Characterization of the 3p12.3-pcen regi

Characterization of the 3p12.3-pcen region associated with tumor suppression in a novel ovarian cancer cell line model genetically modified by chromosome 3 fragment transfer

✍ Neal A.L. Cody; Zhen Shen; Jean-Sebastien Ripeau; Diane M. Provencher; Anne-Mari 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB

## Abstract The genetic analysis of nontumorigenic radiation hybrids generated by transfer of chromosome 3 fragments into the tumorigenic OV‐90 ovarian cancer cell line identified the 3p12.3‐p__cen__ region as a candidate tumor suppressor gene (TSG) locus. In the present study, polymorphic microsat