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Trisomy 12 is a consistent chromosomal aberration in benign ovarian tumors

✍ Scribed by Dr. Tanja Pejovic; Sverre Heim; Nils Mandahl; Bengt Elmfors; Ulla-Maria Flodérus; Stefan Furgyik; Góran Helm; Helena Willén; Felix Mitelman

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
422 KB
Volume
2
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

Clonal karyotypic abnormalities were detected in 7 of 42 cytogenetically analyzed benign ovarian tumors. An adenofibroma had –X and a mucinous cystadenoma had t(1;11)(q25;q23) as the sole abnormality. Trisomy 12 was found in the remaining five tumors. It was the only change in two fibromas and a serous cystadenoma; the fourth tumor, a mucinous cystadenoma, had one clone with + 12 and one with + 12 and + 10, and the fifth tumor, a fibrothecoma, had +4, +9, +12. The finding of trisomy 12 in five of seven karyotypically aberrant tumors suggests that this aberration characterizes a hitherto unrecognized cytogenetic subgroup of benign ovarian neoplasms.

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