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Chromosome 1 abnormalities in relapse and terminal stages in childhood leukemia

✍ Scribed by Morse, Helvise ;Hays, Taru ;Rose, Barbara ;Robinson, Arthur

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
345 KB
Volume
7
Category
Article
ISSN
0098-1532

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✦ Synopsis

Seven of 114 children with leukemia were shown to have abnormalities of chromosome 1. These included trisomy of parts of chromosome 1 as well as translocations of chromosome 1 to other chromosomes. The abnormalities were found during a relapse or terminal stage, after which the patient was refractory to therapy in all cases.

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## Abstract The successful induction and maintenance of hematologic remission in childhood acute leukemia has led to the recognition of extramedullary leukemia as a major clinical problem [1–6]. The central nervous system is the most common site of extramedullary relapse [1,7–12], A more recently r