We present a patient with APL because of the therapeutic implications of the singular chromosomal rearrangement present in his leukemic cells. Our patient is a 60-year-old male who presented with easy bruisability, gum bleeding, weakness, decreased appetite, and night sweats. He is a retired admiral
Chromosome abnormalities in acute promyelocytic leukemia (APL)
โ Scribed by Dr. H. Van Den Berghe; A. Louwagie; A. Broeckaert Van Orshoven; G. David; R. Verwilghen; J. L. Michaux; G. Sokal
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 397 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0008-543X
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Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,
Twenty-four patients with acute promyelocytic leukemia were reviewed. Group I, treated between July 1970 and September 1973, received arabinosylcytosine and 6-thioguanine, and there was one complete remission, with 4 7 dying during induction with intracerebral hemorrhages, and 217 dying within one m
Acute promyelocytic leukemia (APL) is a subset of acute myeloid leukemia characterized by the morphology of the blast cells (M3 type in the FAB nomenclature), and a specific t(15;17) translocation. APL was further characterized by a specific sensitivity to all-trans retinoic acid's differentiation e