Six hundred thirty-four children with acute lymphoblastic leukemia (ALL) were randomized to receive sanctuary therapy consisting of either cranial irradiation (CRT) plus intrathecal (IT) methotrexate (MTX) or three courses of intermediate-dose methotrexate (IDM) plus intrathecal methotrexate. Two hu
Testicular relapse in acute childhood leukemia
β Scribed by John B. Forrest; Hernan Sabio; Stuart S. Howards
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 352 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
The successful induction and maintenance of hematologic remission in childhood acute leukemia has led to the recognition of extramedullary leukemia as a major clinical problem [1β6]. The central nervous system is the most common site of extramedullary relapse [1,7β12], A more recently recognized form of extramedullary relapse is the testis [13β22]. This paper will review a series of patients with childhood acute leukemia who suffered testicular relapse. Modes of therapy for testicular relapse and research conducted into the etiology of testicular relapse will be discussed.
π SIMILAR VOLUMES
The clinical course and other distinctive features of five children who developed a testicular relapse 4 months to 25 months after the diagnosis of acute nonlymphoblastic leukemia (ANLL) are described. The chief presenting feature at relapse was painless testicular enlargement, as is also seen in ch