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Chromosomal autonomy of hMLH1 methylation in colon cancer

✍ Scribed by Li, Hui; Myeroff, Lois; Kasturi, Lakshmi; Krumroy, Lisa; Schwartz, Stuart; Willson, James KV; Stanbridge, Eric; Casey, Graham; Markowitz, Sanford

Book ID
110066456
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
196 KB
Volume
21
Category
Article
ISSN
0950-9232

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i